EPHA1 - EPH receptor A1
Entrez Gene Name: EPH receptor A1
Entrez GeneID: Human(2041)
, Mouse(13835), Rat(312279)
, Mouse(13835), Rat(312279) Synonyms: 5730453L17Rik, AL033318, EPH, EPH1, EPHA1, EPHT, EPHT1, Esk, MGC163163
Gene Summary
- Human (2041): This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
protein amino acid phosphorylation, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
Literature References
- 15561600Surawska H, Ma PC, Salgia R. The role of ephrins and Eph receptors in cancer.Cytokine Growth Factor Rev 2004 Dec 01;15(6):419-33
- 15093606Noren NK, Pasquale EB. Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins.Cell Signal 2004 Jun 01;16(6):655-66
- 12077243Muñoz JJ, Alonso-C LM, Sacedón R, Crompton T, Vicente A, Jiménez E, Varas A, Zapata AG. Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus.J Immunol 2002 Jul 1;169(1):177-84 View 155 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ephrin receptor activity, kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity
Protein Domains
ATPase activity, coupled to transmembrane movement of substances, extracellular domain, Fibronectin type III domain, kinase, ligand-binding domain, protein serine/threonine kinase, protein-tyrosine kinase, SAM domain, transmembrane receptor protein tyrosine kinase
