CASP2 - caspase 2, apoptosis-related cysteine peptidase
Entrez Gene Name: caspase 2, apoptosis-related cysteine peptidase
Entrez GeneID: Human(835)
, Mouse(12366), Rat(64314)
, Mouse(12366), Rat(64314) Synonyms: CASP2, CASPASE-2, ICH-1, ICH-1L, ICH-1L/1S, NEDD2
Gene Summary
- Human (835): This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq]
- Rat (64314): may play a role in proteolysis and programmed cell death [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, induction of apoptosis, negative regulation of apoptosis, positive regulation of apoptosis, programmed cell death, protein maturation by peptide bond cleavage, proteolysis, regulation of apoptosis
Literature References
- 16193064Shin S, Lee Y, Kim W, Ko H, Choi H, Kim K. Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.EMBO J 2005 Oct 19;24(20):3532-42
- 14556717Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death.Neuron 2003 Oct 09;40(2):401-13
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363 View 2114 categorized literature findings and their references in IPA
Molecular Functions
cysteine-type endopeptidase activity, cysteine-type peptidase activity, enzyme binding, hydrolase activity, identical protein binding, peptidase activity, protein binding, protein domain specific binding
Protein Domains
Card domain, caspase domain, enzyme binding, peptidase, protein binding, protein self binding
Subcellular Locations
cytoplasm, cytosol, cytosolic fraction, Golgi apparatus, microsomal fraction, mitochondria, mitochondrial fraction, nuclear fraction, nucleus
