CDK5 - cyclin-dependent kinase 5
Entrez Gene Name: cyclin-dependent kinase 5
Entrez GeneID: Human(1020)
, Mouse(12568), Rat(140908)
, Mouse(12568), Rat(140908) Synonyms: AW048668, CDK5, Crk6, MGC140720, Neuronal cdc2-like kinase, PSSALRE
Gene Summary
- Rat (140908): serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, associative learning, axon extension, axonogenesis, behavioral response to cocaine, cell cycle, cell division, cell migration, cell proliferation, cell-matrix adhesion, central nervous system development, central nervous system neuron development, cerebellar cortex development, cerebellar cortex formation, cerebellum development, cerebral cortex development, corpus callosum development, cortical actin cytoskeleton organization, dendrite morphogenesis, embryonic development, exocytosis, forebrain development, hippocampus development, intracellular protein transport, layer formation in the cerebral cortex, motor axon guidance, negative regulation of cell cycle, negative regulation of protein export from nucleus, negative regulation of protein ubiquitination, negative regulation of synaptic plasticity, neuron apoptosis, neuron differentiation, neuron migration, neuron projection development, neuron projection morphogenesis, peptidyl-serine phosphorylation, positive regulation of calcium ion-dependent exocytosis, positive regulation of neuron apoptosis, positive regulation of protein kinase activity, protein amino acid autophosphorylation, protein amino acid phosphorylation, receptor catabolic process, receptor clustering, regulated secretory pathway, regulation of cell migration, regulation of excitatory postsynaptic membrane potential, regulation of postsynaptic membrane potential, regulation of synaptic plasticity, response to cocaine, response to wounding, Schwann cell development, sensory perception of pain, serine phosphorylation of STAT3 protein, skeletal muscle tissue development, synaptic transmission, dopaminergic, synaptic transmission, glutamatergic, synaptic vesicle endocytosis, telencephalon development, visual learning
Cellular Components
axon, cell junction, cell projection, cell soma, cyclin-dependent protein kinase 5 activator complex, cytoplasm, cytoskeleton, cytosol, dendrite, filopodium, growth cone, lamellipodium, membrane, neuromuscular junction, nuclear part, nucleolus, nucleus
Literature References
- 17218253Ayala R, Shu T, Tsai LH. Trekking across the brain: the journey of neuronal migration.Cell 2007 Jan 12;128(1):29-43
- 12691662Gong X, Tang X, Wiedmann M, Wang X, Peng J, Zheng D, Blair LA, Marshall J, Mao Z. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.Neuron 2003 Apr 10;38(1):33-46
- 12536130Salehi A, Delcroix JD, Mobley WC. Traffic at the intersection of neurotrophic factor signaling and neurodegeneration.Trends Neurosci 2003 Feb 01;26(2):73-80 View 1450 categorized literature findings and their references in IPA
Molecular Functions
acetylcholine receptor activator activity, ATP binding, cyclin-dependent protein kinase activity, ErbB-2 class receptor binding, ErbB-3 class receptor binding, kinase activity, nucleotide binding, p53 binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, tau-protein kinase activity, transferase activity
Protein Domains
acetylcholine receptor agonist, Alcohol group acceptor phosphotransferase, cyclin-dependent protein kinase, kinase, Neu/ErbB-2 receptor binding, protein binding, Protein kinase, protein serine/threonine kinase, Tau-protein kinase
Subcellular Locations
actin cytoskeleton, axons, cell body, cell periphery, cellular membrane, cytoplasm, cytoplasmic cytoskeleton, cytoplasmic fraction, cytoskeletal fraction, cytosolic fraction, dendrites, dendritic shafts, dendritic spines, detergent-insoluble fractions, detergent-soluble fraction, growth cone, intermediate filaments, lamellipodia, membrane fraction, membrane ruffles, microspikes, microtubule fractions, microtubules, neurites, nuclear fraction, nucleus, outer dense fibers, perinuclear region, soluble fraction, sperm tail, synaptic plasma membrane fractions, synaptosomal fractions, vesicle fraction
