EIF2AK2 - eukaryotic translation initiation factor 2-alpha kinase 2
Entrez Gene Name: eukaryotic translation initiation factor 2-alpha kinase 2
Entrez GeneID: Human(5610)
, Mouse(19106), Rat(54287)
, Mouse(19106), Rat(54287) Synonyms: 2310047A08Rik, 4732414G15Rik, AI467567, AI747578, DAI, DOUBLE STRANDED RNA DEPENDENT PROTEIN KINASE, EIF2AK1, EIF2AK2, GCN4, IFNPKR, MGC126524, p68 kinase, PKR, PRKR, Tik
Gene Summary
- Rat (54287): double-stranded RNA dependent eukaryotic initiation factor 2-kinase [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
endoplasmic reticulum unfolded protein response, interspecies interaction between organisms, negative regulation of cell proliferation, positive regulation of apoptosis, protein amino acid autophosphorylation, protein amino acid phosphorylation, response to exogenous dsRNA, response to lipopolysaccharide, response to mechanical stimulus, response to organic substance, response to toxin, response to virus, response to vitamin E, translation, virus-infected cell apoptosis
Literature References
- 14765129Onuki R, Bando Y, Suyama E, Katayama T, Kawasaki H, Baba T, Tohyama M, Taira K. An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease.EMBO J 2004 Feb 25;23(4):959-68
- 11447118Donzé O, Abbas-Terki T, Picard D. The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR.EMBO J 2001 Jul 16;20(14):3771-80
- 11350938Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR. Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.EMBO J 2001 May 15;20(10):2487-96 View 1793 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, double-stranded RNA binding, eukaryotic translation initiation factor 2alpha kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein phosphatase type 2A regulator activity, protein serine/threonine kinase activity, RNA binding, transferase activity, translation initiation factor activity
Protein Domains
Alcohol group acceptor phosphotransferase, catalytic domain, coiled-coil domain, double-stranded RNA binding, dsRNA-binding domain, eukaryotic translation initiation factor 2alpha kinase, kinase, kinase domain, leucine zipper domain, protein binding, Protein kinase, protein phosphatase type 2A, intrinsic regulator, protein serine/threonine kinase
