PAK1 - p21 protein (Cdc42/Rac)-activated kinase 1
Entrez Gene Name: p21 protein (Cdc42/Rac)-activated kinase 1
Entrez GeneID: Human(5058)
, Mouse(18479), Rat(29431)
, Mouse(18479), Rat(29431) Synonyms: Alpha Pak, AW045634, MGC130000, MGC130001, Muk2, Pak, PAK1, PAK1B, PAKA, PAKALPHA
Gene Summary
- Human (5058): PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Rat (29431): serine/threonine protein kinase; binds and forms complex specifically with activated (GTP-bound) p21, leading to inhibiting p21 GTPase activity [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, cellular response to insulin stimulus, cellular response to stress, cytoskeleton organization, dendrite development, ER-nuclear signaling pathway, MAPKKK cascade, neuromuscular junction development, neuron projection morphogenesis, positive regulation of JUN kinase activity, protein amino acid autophosphorylation, protein amino acid phosphorylation, protein kinase cascade, receptor clustering, regulation of actin cytoskeleton organization, response to hypoxia, response to organic substance, small GTPase mediated signal transduction
Cellular Components
axon, cell junction, cytoplasm, cytosol, dendrite, focal adhesion, Golgi apparatus, growth cone, intercalated disc, membrane fraction, nuclear membrane, nucleus, plasma membrane, Z disc
Literature References
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 12887923Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, Smrcka AV, Wu G, Li L, Liu M, Huang CK, Wu D. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.Cell 2003 Jul 25;114(2):215-27
- 12374744Wang RA, Mazumdar A, Vadlamudi RK, Kumar R. P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.EMBO J 2002 Oct 15;21(20):5437-47 View 1755 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, catalytic activity, collagen binding, kinase activity, MAP kinase kinase kinase activity, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, transferase activity
- FAK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Semaphorin Signaling in Neurons
- Molecular Mechanisms of Cancer
- Renal Cell Carcinoma Signaling
- Angiopoietin Signaling
- Axonal Guidance Signaling
- HGF Signaling
- Ephrin Receptor Signaling
- Nicotinate and Nicotinamide Metabolism
- Inositol Phosphate Metabolism
- Agrin Interactions at Neuromuscular Junction
- GNRH Signaling
- LPS-stimulated MAPK Signaling
- Cdc42 Signaling
- Natural Killer Cell Signaling
- Macropinocytosis Signaling
- Regulation of Actin-based Motility by Rho
- Actin Cytoskeleton Signaling
- Integrin Signaling
- CXCR4 Signaling
- Amyotrophic Lateral Sclerosis Signaling
- CCR3 Signaling in Eosinophils
- Renin-Angiotensin Signaling
- IL-3 Signaling
- ERK/MAPK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- CD28 Signaling in T Helper Cells
- G Beta Gamma Signaling
Protein Domains
Alcohol group acceptor phosphotransferase, carboxy terminal domain, CDC42/Rac interactive binding domain, collagen binding, kinase, MAP kinase kinase kinase, N-terminal domain, Nck-binding domain, p21 binding domain, Pak binding domain, protein binding, Protein kinase, protein kinase binding, protein serine/threonine kinase, regulatory domain
Subcellular Locations
cell membrane leading edge, chromatin fraction, cytoplasm, cytosolic fraction, filopodial tip, focal adhesions, growth cone, lamellipodia, membrane ruffles, nuclear matrix, plasma membrane, synaptic membrane, vesicles
