ERBB2 - v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Entrez Gene Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Entrez GeneID: Human(2064)
, Mouse(13866), Rat(24337)
, Mouse(13866), Rat(24337) Synonyms: C-ERBB2, c-neu, CD340, EGFR2, ERBB2, ERBB2 RECEPTOR, HER-2, HER2/NEU, mKIAA3023, NEU, NGL, p185erbb2, p185HER2, P185NEU, TKR1, V-ERBB2 NEURO/GLIOBLASTOMA-DERIVED ONCOGENE
Gene Summary
- Human (2064): This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]
- Rat (24337): may play a role in cell proliferation and differentiation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell proliferation, cell surface receptor linked signal transduction, central nervous system development, estrus, glial cell differentiation, heart development, liver development, mammary gland development, mammary gland involution, motor axon guidance, myelination, negative regulation of apoptosis, negative regulation of immature T cell proliferation in the thymus, nervous system development, neuromuscular junction development, peripheral nervous system development, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, positive regulation of cell adhesion, positive regulation of cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of MAP kinase activity, positive regulation of MAPKKK cascade, positive regulation of phosphoinositide 3-kinase cascade, positive regulation of Ras protein signal transduction, protein amino acid autophosphorylation, protein amino acid phosphorylation, regulation of angiogenesis, regulation of cell differentiation, regulation of cell proliferation, response to axon injury, response to drug, response to progesterone stimulus, skeletal muscle tissue development, sympathetic nervous system development, tongue development, transmembrane receptor protein tyrosine kinase signaling pathway, wound healing
Cellular Components
apical plasma membrane, basal plasma membrane, basolateral plasma membrane, cytoplasm, integral to membrane, lateral loop, membrane, membrane raft, microvillus, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic membrane, receptor complex
Literature References
- 17570480Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MW, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang TH, Yang T, Park BK, Wang CY, Zheng P, Liu Y. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.Cell 2007 Jun 29;129(7):1275-86
- 16273093Jones RB, Gordus A, Krall JA, MacBeath G. A quantitative protein interaction network for the ErbB receptors using protein microarrays.Nature 2006 01 12;439(7073):168-74
- 15822187Drummond DC, Noble CO, Kirpotin DB, Guo Z, Scott GK, Benz CC. Clinical development of histone deacetylase inhibitors as anticancer agents.Annu Rev Pharmacol Toxicol 2005 Jan 01;45:495-528 View 5534 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, epidermal growth factor receptor activity, ErbB-3 class receptor binding, glycoprotein binding, growth factor binding, Hsp90 protein binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein C-terminus binding, protein heterodimerization activity, protein kinase activity, protein phosphatase binding, protein tyrosine kinase activity, receptor activity, receptor signaling protein tyrosine kinase activity, transferase activity, transmembrane receptor activity, transmembrane receptor protein tyrosine kinase activity, ubiquitin protein ligase binding
Protein Domains
Bcl-2 homology 3 domain, cytoplasmic domain, cytosolic tail domain, epidermal growth factor receptor, extracellular domain, Furin-like cysteine rich domain, Grb2 binding domain, growth factor binding, intracellular domain, kinase, kinase domain, L domain, non-membrane spanning protein tyrosine kinase, protein binding, protein heterodimerization, protein self binding, protein-tyrosine kinase, receptor signaling protein tyrosine kinase, Shc binding site, transmembrane receptor, transmembrane receptor protein tyrosine kinase
Subcellular Locations
apical membrane, basolateral membrane, caveolae, cell cortex, cell periphery, cell surface, cellular membrane, cytoplasm, detergent-insoluble fractions, detergent-soluble fraction, filopodia, lamellipodia, lateral cell surfaces, membrane blebs, membrane fraction, membrane rafts, microvilli, neurofilaments, neuromuscular junctions, nucleus, perinuclear region, plasma membrane, plasma membrane projections, postsynaptic density (PSD) fractions, postsynaptic membrane, synaptic membrane, synaptic plasma membrane fractions, synaptosomes, transverse tubules
