CDK2 - cyclin-dependent kinase 2
Entrez Gene Name: cyclin-dependent kinase 2
Entrez GeneID: Human(1017)
, Mouse(12566), Rat(362817)
, Mouse(12566), Rat(362817) Synonyms: A630093N05Rik, CDK2, Cyclin A associated kinase, CYCLIN E ASSOCIATED KINASE, CYCLIN E-DEPENDENT KINASE, p33(CDK2), p33CDK2
Gene Summary
- Human (1017): The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle, cell division, cellular response to insulin stimulus, G2/M transition of mitotic cell cycle, mitosis, organ regeneration, positive regulation of cell proliferation, positive regulation of transcription, potassium ion transport, protein amino acid phosphorylation, regulation of DNA replication, response to cadmium ion, response to cAMP, response to drug, response to electrical stimulus, response to estradiol stimulus, response to ethanol, response to toxin, traversing start control point of mitotic cell cycle
Cellular Components
chromosome, telomeric region, condensed chromosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, microsome, nucleoplasm, nucleus, transcription factor complex, X chromosome, Y chromosome
Literature References
- 17254966Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, Waddell MB, Jäkel H, Kullmann M, Kriwacki RW, Hengst L. Cdk-Inhibitory Activity and Stability of p27(Kip1) Are Directly Regulated by Oncogenic Tyrosine Kinases.Cell 2007 Jan 26;128(2):269-80
- 15232106Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J. Self-assembling protein microarrays.Science 2004 07 2;305(5680):86-90
- 11533444Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.Science 2001 Oct 5;294(5540):173-7 View 3872 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, cyclin-dependent protein kinase activity, histone kinase activity, identical protein binding, kinase activity, nucleotide binding, protein binding, protein complex binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
- Aryl Hydrocarbon Receptor Signaling
- Inositol Phosphate Metabolism
- p53 Signaling
- HGF Signaling
- Nicotinate and Nicotinamide Metabolism
- Small Cell Lung Cancer Signaling
- ATM Signaling
- Molecular Mechanisms of Cancer
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Cell Cycle Regulation by BTG Family Proteins
- Cell Cycle: G1/S Checkpoint Regulation
- Role of CHK Proteins in Cell Cycle Checkpoint Control
Protein Domains
Alcohol group acceptor phosphotransferase, cyclin-binding domain, cyclin-dependent protein kinase, kinase, protein binding, protein self binding, protein serine/threonine kinase
Subcellular Locations
centrosome, cytoplasm, cytoplasmic fraction, cytosol, cytosolic fraction, endosomes, nuclear fraction, nucleoli, nucleus, perinuclear region, plasma membrane
