RARA - retinoic acid receptor, alpha
Entrez Gene Name: retinoic acid receptor, alpha
Entrez GeneID: Human(5914)
, Mouse(19401), Rat(24705)
, Mouse(19401), Rat(24705) Synonyms: ALPHA RAR, NR1B1, RAR, RAR ALPHA, RAR ALPHA 1, RARA, RETINOIC ACID RECEPTOR ALPHA
Gene Summary
- Human (5914): Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM]
- Rat (24705): mediates all-trans-retinoic acid induction of mitogen-activated protein kinase phosphatase 1 (MKP-1); contributes to regulation of oxidative stress-induced anti-apoptosis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
estrogen receptor signaling pathway, negative regulation of gene expression, negative regulation of interferon-gamma production, negative regulation of transcription, negative regulation of transcription from RNA polymerase II promoter, negative regulation of tumor necrosis factor production, positive regulation of cell proliferation, positive regulation of interleukin-13 production, positive regulation of interleukin-4 production, positive regulation of interleukin-5 production, positive regulation of T-helper 2 cell differentiation, positive regulation of transcription from RNA polymerase II promoter, regulation of anti-apoptosis, regulation of transcription, regulation of transcription, DNA-dependent, response to estradiol stimulus, response to retinoic acid, retinoic acid receptor signaling pathway, signal transduction, transcription, ureteric bud development, ventricular cardiac muscle cell differentiation
Literature References
- 11805839Germain P, Iyer J, Zechel C, Gronemeyer H. Co-regulator recruitment and the mechanism of retinoic acid receptor synergy.Nature 2002 Jan 10;415(6868):187-92
- 11439184McNamara P, Seo SP, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.Cell 2001 Jun 29;105(7):877-89
- 17641689Lee HK, Park UH, Kim EJ, Um SJ. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.EMBO J 2007 08 8;26(15):3545-57 View 3505 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, ligand-dependent nuclear receptor activity, metal ion binding, protein binding, receptor activity, retinoic acid binding, retinoic acid receptor activity, sequence-specific DNA binding, steroid hormone receptor activity, transcription coactivator activity, transcription factor activity, transcription regulator activity, transcription repressor activity, zinc ion binding
Protein Domains
C4 type zinc finger domain, carboxy terminal domain, DNA binding, DNA binding domain, E domain, Fxfp sequence, helix-loop-helix domain, ligand-binding domain, ligand-dependent nuclear receptor, protein binding, retinoic acid receptor, silencing domain, transcription co-activator, transcription factor, transcription regulator, transcriptional repressor
Subcellular Locations
cytoplasm, cytosol, nuclear fraction, nucleoplasm, nucleus, perinuclear region
