PARK2 - Parkinson disease (autosomal recessive, juvenile) 2, parkin
Entrez Gene Name: Parkinson disease (autosomal recessive, juvenile) 2, parkin
Entrez GeneID: Human(5071)
, Mouse(50873), Rat(56816)
, Mouse(50873), Rat(56816) Synonyms: AR-JP, LPRS2, MGC130518, Park, PARK2, PARKIN, PDJ, PRKN
Gene Summary
- Human (5071): The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq]
- Rat (56816): localized to the cytoplasm in neurons of many regions of the brain; has N-terminal ubiquitin and ring-IBR-ring finger domains [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
adult locomotory behavior, central nervous system development, dopamine metabolic process, dopamine uptake, learning, locomotory behavior, modification-dependent protein catabolic process, neuron maturation, norepinephrine metabolic process, protein metabolic process, protein modification process, protein ubiquitination during ubiquitin-dependent protein catabolic process, regulation of neurotransmitter secretion, regulation of synaptic transmission, response to corticosterone stimulus, response to drug, response to unfolded protein, startle response, synaptic transmission, dopaminergic, synaptic transmission, glutamatergic, ubiquitin-dependent protein catabolic process
Cellular Components
cell junction, cell projection, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, Golgi apparatus, Golgi membrane, intracellular, membrane, membrane raft, neuron projection, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, postsynaptic membrane, protein complex, synapse, synaptic vesicle
Literature References
- 16096643Sato S, Chiba T, Sakata E, Kato K, Mizuno Y, Hattori N, Tanaka K. 14-3-3eta is a novel regulator of parkin ubiquitin ligase.EMBO J 2006 01 11;25(1):211-21
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 15603737Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM. BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron Degeneration.Neuron 2004 Dec 16;44(6):931-45 View 1035 categorized literature findings and their references in IPA
Molecular Functions
acid-amino acid ligase activity, ligase activity, metal ion binding, protein binding, protein complex binding, ubiquitin-protein ligase activity, zinc ion binding
Protein Domains
enzyme, In Between Ring Finger Domain, linker domain, protein binding, RING domain, ubiquitin-like domain, Ubiquitin-protein ligase
Subcellular Locations
cell body, cytoplasm, cytosol, detergent-soluble fraction, endoplasmic reticulum, insoluble fractions, membrane processes, membrane rafts, microtubule fractions, microtubules, mitochondrial outer membrane, neurites, nucleus, perikaryon, perinuclear region, plasma membrane, plasma membrane fraction, postsynaptic density (PSD) fractions, synaptic plasma membrane fractions, synaptic vesicle fractions, synaptosomal fractions, vesicle fraction
