EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry

Synthesis of potent oxindole CDK2 inhibitors.


PMID 12659774

Abstract

A series of oxindole CDK2 inhibitors was synthesized. These novel analogues have a saturated monosubstituted cyclic moiety at their C-4 position that mimics the ribofuranoside of ATP. This substitution afforded agents with increased potency relative to the parent indolinone and nanomolar range IC(50) against the CDK2 enzyme and two cancer cell lines.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

540935
4-(N-Boc-amino)piperidine, 96%
C10H20N2O2