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Bioorganic & medicinal chemistry letters

Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities.


PMID 14980663

Abstract

Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H(quinazolino-4-one)]quinoline (7) were synthesized. The new analogues, along with four natural quinazoline-quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC(50) 1.8-40.0 microg/mL) and DNA topoisomerase II inhibition at a concentration of 25 microM.

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L4045 Luotonin A, ≥98% (HPLC)
L5045 Luotonin B, ≥98%
C18H11N3O2
L4920 Luotonin E, ≥98%
C19H13N3O2