EMAIL THIS PAGE TO A FRIEND

Journal of natural products

Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species.


PMID 15679323

Abstract

Fifteen stilbenoids and two alkaloids from Stemona collinsae, S. tuberosa, and S. peirrei were tested alongside the commercially available stilbenoids resveratrol and pinosylvin for inhibition of leukotriene formation in an ex vivo test system based on activated human neutrophilic granulocytes. The stilbenoids resveratrol (1), pinosylvin (2), dihydropinosylvin (3), stilbostemin A (4), stilbostemin B (5), stilbostemin D (6), stilbostemin F (7), stilbostemin G (8), stemofuran B (9), stemofuran C (10), stemofuran D (11), stemofuran G (12), stemofuran J (13), stemanthrene A (14), stemanthrene B (15), stemanthrene C (16), and stemanthrene D (17) showed structure-dependent activities with IC(50) values ranging from 3.7 to >50 microM. The alkaloids tuberostemonine (18) and neotuberostemonine (19) were inactive at a concentration of 50 microM.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

69061
Dihydropinosylvin monomethyl ether, ≥97.0% (HPLC)
C15H16O2
56297
Pinosylvin, ≥97.0% (HPLC)
C14H12O2