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Bioorganic & medicinal chemistry letters

Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones.


PMID 15837311

Abstract

A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.