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Organic letters

Suzuki coupling of aryl chlorides with phenylboronic acid in water, using microwave heating with simultaneous cooling.


PMID 15901144

Abstract

[reaction: see text]. We present here a methodology for the Suzuki coupling of aryl chlorides with phenylboronic acid using Pd/C as a catalyst, water as a solvent, and microwave heating. We show that simultaneous cooling in conjunction with microwave heating prolongs the lifetime of the aryl chloride substrates during the course of the reaction and, as a result, yields of the desired biaryl as well as overall recovery of material can be increased.

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78181
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