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Bioorganic & medicinal chemistry letters

Synthesis of substituted indole derivatives as a new class of antimalarial agents.


PMID 15925306

Abstract

A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1 microg/mL. These compounds are in vitro several folds more active than pyrimethamine.