EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry

Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate.


PMID 16084097

Abstract

We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA-HCPT. The antitumor activity of DHA-HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia, Lewis lung carcinoma, and colon 38 adenocarcinoma. DHA-HCPT showed a greatly improved antitumor efficacy compared to HCPT.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

534498
4-Piperidinopiperidine, 97%
C10H20N2