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Bioorganic & medicinal chemistry letters

Design and semisynthesis of novel fredericamycin A derivatives with an improved antitumor profile.


PMID 16621542

Abstract

We report the design, semisynthesis, and biological activity of a series of fredericamycin (1) derivatives. Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model.