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Bioorganic & medicinal chemistry letters

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.


PMID 16632357

Abstract

Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERbeta subtype selective ligands are described. Several analogs possessing ERbeta binding affinities comparable to 17beta-estradiol but with greater than 75-fold selectivity over ERalpha are reported.