EMAIL THIS PAGE TO A FRIEND

Journal of medicinal chemistry

Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.


PMID 16640326

Abstract

We report the synthesis and pharmacological properties of several cytisine derivatives. Among them, two 10-substituted derivatives showed much higher selectivities for the alpha4beta2 nAChR subtype in binding assays than cytisine. The 9-vinyl derivative was found to have a very similar agonist activity profile to that of cytisine.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

700614
2-Chloro-6-methoxypyridine-4-carboxylic acid
C7H6ClNO3
C2899
Cytisine, ≥99%, powder
C11H14N2O