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Bioorganic & medicinal chemistry letters

New rifabutin analogs: synthesis and biological activity against Mycobacterium tuberculosis.


PMID 16987658

Abstract

The synthesis, structure, and biological evaluation of a series of novel rifamycin derivatives, Rifastures (RFA) with potent anti-tuberculosis activity are presented. Some of these derivatives showed higher in vitro activity than rifabutin and rifampicin against not only Mycobacterium tuberculosis strains but also against MAC and Mycobacterium kansasii.