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Bioorganic & medicinal chemistry letters

Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug.


PMID 16987659

Abstract

Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.