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Organic letters

Radical trifluoromethylation of ketone silyl enol ethers by activation with dialkylzinc.


PMID 17020274

Abstract

[reaction: see text] The radical trifluoromethylation of ketone silyl enol ethers gave alpha-CF(3) ketones in good yields with wide scope of the ketonic substrates including acyclic ketones and cyclopentanone. The use of dialkylzinc to activate the silyl enol ethers is the key to the efficient radical trifluoromethylation.

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