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Clinical oncology (Royal College of Radiologists (Great Britain))

Ifosfamide encephalopathy.


PMID 17355105

Abstract

Encephalopathy is a potentially fatal toxicity of ifosfamide. Clinical manifestations of encephalopathy range from fatigue and confusion to coma and death. Early identification of this toxicity and prompt cessation of ifosfamide are the essential elements in the management of ifosfamide encephalopathy. Accurate prediction of this toxicity is often difficult. Based on the limited available evidence, methylene blue, an electron acceptor, may have a role in the treatment and the prevention of neurotoxicity. This paper reviews the current understanding of ifosfamide encephalopathy.

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I0060000
Ifosfamide, European Pharmacopoeia (EP) Reference Standard
C7H15Cl2N2O2P