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Bioorganic & medicinal chemistry letters

Synthesis of benzothiazole semicarbazones as novel anticonvulsants--the role of hydrophobic domain.


PMID 17572089

Abstract

A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES screen. Selected compounds were checked for their lipophilic character.