EMAIL THIS PAGE TO A FRIEND

Accounts of chemical research

Iridium-catalyzed asymmetric hydrogenation of olefins.


PMID 17672517

Abstract

Asymmetric hydrogenation is one of the most important catalytic methods for the preparation of optically active compounds. For a long time the range of olefins that could be hydrogenated with high enantiomeric excess was limited to substrates bearing a coordinating group next to the C+C bond. We have found a new class of catalysts, iridium complexes with chiral P, N ligands, that overcome these limitations. For a wide range of unfunctionalized olefins, excellent enantioselectivities could be achieved. Because these catalysts do not require the presence of any particular functional group in the substrate, they considerably broaden the scope of asymmetric hydrogenation. In addition, promising results were also obtained with certain functionalized alkenes, furans, and benzofurans.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

449229
Iridium, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.9% trace metals basis
Ir
357332
Iridium, foil, thickness 0.1 mm, 99.5% trace metals basis
Ir
357324
Iridium, foil, thickness 0.25 mm, 99.9% trace metals basis
Ir
209686
Iridium, powder, 99.9% trace metals basis
Ir
336793
Iridium, black, powder, −200 mesh, ≥99% trace metals basis
Ir
266841
Iridium, wire, diam. 0.15 mm, 99.9% trace metals basis
Ir
GF35321172
Iridium, rod, 50mm, diameter 3.0mm, as drawn, 99.9%
Ir
GF07750795
Iridium, wire reel, 0.025m, diameter 2.0mm, as drawn, 99.9%
Ir
GF44052667
Iridium, wire reel, 0.05m, diameter 0.075mm, as drawn, 99.9%
Ir
GF97286428
Iridium, wire reel, 0.05m, diameter 0.1mm, as drawn, 99.9%
Ir
GF22425375
Iridium, wire reel, 0.05m, diameter 0.8mm, as drawn, 99.9%
Ir
GF68849544
Iridium, wire reel, 0.05m, diameter 2.0mm, as drawn, 99.9%
Ir
GF06583394
Iridium, wire reel, 0.1m, diameter 0.075mm, as drawn, 99.9%
Ir
GF65585021
Iridium, wire reel, 0.1m, diameter 0.125mm, as drawn, 99.5%
Ir
GF88210447
Iridium, wire reel, 0.1m, diameter 0.125mm, as drawn, 99.9%
Ir
GF26409247
Iridium, wire reel, 0.1m, diameter 0.15mm, as drawn, 99.9%
Ir
GF60803412
Iridium, wire reel, 0.1m, diameter 0.1mm, as drawn, 99.9%
Ir
GF31863607
Iridium, wire reel, 0.1m, diameter 0.25mm, as drawn, 99.9%
Ir
GF99945534
Iridium, wire reel, 0.1m, diameter 0.2mm, as drawn, 99.9%
Ir
GF36309450
Iridium, wire reel, 0.1m, diameter 0.38mm, as drawn, 99.9%
Ir
GF50407062
Iridium, wire reel, 0.1m, diameter 0.5mm, as drawn, 99.9%
Ir
GF80911403
Iridium, wire reel, 0.1m, diameter 0.8mm, as drawn, 99.9%
Ir
GF06192930
Iridium, wire reel, 0.1m, diameter 2.0mm, as drawn, 99.9%
Ir
GF22923974
Iridium, wire reel, 0.2m, diameter 0.075mm, as drawn, 99.9%
Ir
GF30370924
Iridium, wire reel, 0.2m, diameter 0.125mm, as drawn, 99.5%
Ir
GF26305130
Iridium, wire reel, 0.2m, diameter 0.125mm, as drawn, 99.9%
Ir
GF01155170
Iridium, wire reel, 0.2m, diameter 0.15mm, as drawn, 99.9%
Ir
GF00427250
Iridium, wire reel, 0.2m, diameter 0.1mm, as drawn, 99.9%
Ir
GF82950273
Iridium, wire reel, 0.2m, diameter 0.25mm, as drawn, 99.9%
Ir
GF60570176
Iridium, wire reel, 0.2m, diameter 0.2mm, as drawn, 99.9%
Ir