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Antimicrobial agents and chemotherapy

Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay.


PMID 18025114

Abstract

Calcineurin inhibitors may augment the effects of antifungal drugs in microbiological assays. We examined this interaction in a microbiological assay for posaconazole. No effect was observed. However, concurrent or recently discontinued treatment with other antifungal drugs caused false-positive results, emphasizing a limitation of microbiological assays for antifungal drug level measurement.