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Bioorganic & medicinal chemistry letters

Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors.


PMID 18440814

Abstract

Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa.