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Bioorganic & medicinal chemistry letters

Discovery of a novel class of PPARdelta partial agonists.


PMID 18722772

Abstract

Anthranilic acid GW9371 was identified as a novel class of PPARdelta partial agonist through high-throughput screening. The design and synthesis of SAR analogues is described. GSK1115 and GSK7227 show potent partial agonism of the PPARdelta target genes CPT1a and PDK4 in skeletal muscle cells.

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