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Journal of medicinal chemistry

Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays.


PMID 19530700

Abstract

In this paper, a peptide substrate (Pep8) of TSSK1 is identified. Using Pep8 as a substrate, two homogeneous and efficient assays for TSSK1 inhibitors screening have been developed, including luminescent kinase assay and LC-MS-based high-throughput assay. Two classes of compounds were identified that are able to efficiently inhibit phosphorylation catalyzed by TSSK1.

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Adenosine 5′-triphosphate (ATP) disodium salt hydrate, vial of ~1 mg ATP
C10H14N5Na2O13P3 · xH2O