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Bioorganic & medicinal chemistry letters

Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.


PMID 19910190

Abstract

A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against alpha(2)delta and was profiled in in vivo models of pain and anxiety.