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Mini reviews in medicinal chemistry

An overview of highly optically pure chloramphenicol bases: applications and modifications.


PMID 19929809

Abstract

Chloramphenicol (CAP) is a widely used broad-spectrum antibiotic. As the precursor of CAP, chloramphenicol bases are stereochemically pure agents and could be used as resolution agents, chiral catalysts and so on. This review summarizes these applications and discusses the structural modifications of chloramphenicol bases.