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Biochemical and biophysical research communications

Salivary histatin as an inhibitor of a protease produced by the oral bacterium Bacteroides gingivalis.


PMID 1993059

Abstract

We examined the effect of histatin 5 from human parotid saliva on various proteases. Histatin 5 strongly inhibited a trypsin-like protease produced by Bacteroides gingivalis with an IC50 value of 55 nM. Clostripain was also inhibited (IC50 = 800 nM). Activities of other proteases were not affected significantly. Because B. gingivalis is a suspected periodontal pathogen and its proteolytic enzymes have been considered to be associated with periodontal tissue destruction, it is suggested that salivary histatins play a role as a preventive against periodontal disease.

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H6027
Histatin 5, ≥97% (HPLC)
C133H195N51O33