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Fertility and sterility

Inhibition of cell invasion and protease activity by cholesterol sulfate.


PMID 20334863

Abstract

We demonstrated that cholesterol sulfate (CS) inhibits invasion of a trophoblast cell line and plasmin enzyme activity in a noncompetitive manner by binding to the enzyme itself, suggesting that CS can repress cell invasion by inhibiting proteinases such as those involved in the plasminogen activator/plasmin system. Considering these results, it is possible that CS may act as a signaling molecule between the trophoblast and endometrium, and may regulate the process of implantation.

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C9523
Sodium cholesteryl sulfate
C27H45NaO4S