EMAIL THIS PAGE TO A FRIEND

Proceedings of the American Thoracic Society

Linking genetic susceptibility and T cell activation in beryllium-induced disease.


PMID 20427584

Abstract

Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by beryllium (Be) exposure in the workplace. It is characterized by the accumulation of Be-specific CD4(+) T cells in the lung as well as persistent lung inflammation, culminating in the development of lung fibrosis. CBD occurs in 2 to 16% of Be-exposed workers depending on the individuals' genetic susceptibility and the characteristics of the exposure. Genetic susceptibility to Be-induced disease has been linked to major histocompatibility complex class II molecules. In particular, HLA-DP alleles possessing a glutamic acid at the 69th position of the beta-chain (betaGlu69) are most strongly linked to disease susceptibility. The HLA-DP alleles that present Be to T cells match those implicated in the genetic susceptibility, suggesting that the HLA contribution to disease is based on the ability of those molecules to bind and present Be to T cells. However, the structural features of betaGlu69-containing HLA-DP molecules that explain the disease association remain unknown. We have recently crystallized HLA-DP2, which is the most prevalent of the betaGlu69-containing HLA-DP molecules. Its unique structure, which includes surface exposure of betaGlu69, provides an explanation of the genetic linkage between betaGlu69-containing HLA-DP alleles and Be-induced disease.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

265063
Beryllium, chunks, 99.9%
Be
378135
Beryllium, powder, −325 mesh, ≥99%
Be
GF12366660
Beryllium, rod, 100mm, diameter 7.0mm, 99%
Be
GF41430787
Beryllium, wire reel, 0.05m, diameter 0.85mm, annealed and clean, 99%
Be
GF53985370
Beryllium, wire reel, 0.1m, diameter 0.75mm, annealed and clean, 99%
Be
GF46045627
Beryllium, wire reel, 0.2m, diameter 0.75mm, annealed and clean, 99%
Be
GF95797692
Beryllium, wire reel, 0.5m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF09275823
Beryllium, wire reel, 0.1m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF73403142
Beryllium, wire reel, 0.1m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF58877948
Beryllium, wire reel, 0.1m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF45831236
Beryllium, wire reel, 0.1m, diameter 0.5mm, annealed and clean, 99%
Be
GF96781214
Beryllium, wire reel, 0.1m, diameter 0.6mm, annealed and clean, 99%
Be
GF60949840
Beryllium, wire reel, 0.1m, diameter 0.85mm, annealed and clean, 99%
Be
GF59478586
Beryllium, wire reel, 0.2m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF75393388
Beryllium, wire reel, 0.2m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF59743738
Beryllium, wire reel, 0.2m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF29665086
Beryllium, wire reel, 0.2m, diameter 0.5mm, annealed and clean, 99%
Be
GF98865129
Beryllium, wire reel, 0.2m, diameter 0.6mm, annealed and clean, 99%
Be
GF79324959
Beryllium, wire reel, 0.2m, diameter 0.85mm, annealed and clean, 99%
Be
GF67966385
Beryllium, wire reel, 0.3m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF11051558
Beryllium, wire reel, 0.5m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF34823224
Beryllium, wire reel, 0.5m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF24172703
Beryllium, wire reel, 0.5m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF74474208
Beryllium, wire reel, 10m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF81444764
Beryllium, wire reel, 1m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF52902840
Beryllium, wire reel, 1m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF21588565
Beryllium, wire reel, 1m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF80595793
Beryllium, wire reel, 5m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF02814702
Beryllium, mesh, 5x5mm, nominal aperture 0.13mm, thickness 0.025mm, wire diameter 0.1mm, 100 wires/inch, open area 50%, electro-formed mesh
Be
GF06987224
Beryllium, wire reel, 0.05m, diameter 0.25mm, annealed and clean, 99.7%
Be