EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).


PMID 21129965

Abstract

A series of 23 N-(Pyridin-3-yl)benzamides was synthesized and evaluated for their potential to inhibit human steroid-11β-hydroxylase (CYP11B1) and human aldosterone synthase (CYP11B2). The most potent and selective CYP11B2 inhibitors (IC(50) values 53-166 nM) were further evaluated for their potential to inhibit human CYP17 and CYP19, and no inhibition was observed. Clear evidence was shown for N-(Pyridin-3-yl)benzamides to be a highly selective class of CYP11B2 inhibitors in vitro.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

856525
2-Methyl-1,2-di-3-pyridyl-1-propanone, 96%
C14H14N2O