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European journal of medicinal chemistry

Synthesis and antitumor activity of ureas containing pyrimidinyl group.


PMID 21144621

Abstract

A novel series of ureas containing pyrimidinyl group were designed and synthesized. Some of the prepared compounds showed potential cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that introduction of a sulfide bridge between phenyl and pyrimidinyl rings would be critical for their biological activities.