EMAIL THIS PAGE TO A FRIEND

Journal of natural products

Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp.


PMID 21348447

Abstract

Two new indole spermidine alkaloids, didemnidines A (1) and B (2), have been isolated from the New Zealand ascidian Didemnum sp. The structures of the metabolites, determined by analysis of 2D NMR spectra and confirmed via synthesis, embody an indole-3-glyoxylamide moiety linked to the N(1) position of spermidine, the latter motif being particularly rare among marine natural products. Didemnidine B and a synthetic precursor exhibited mild in vitro growth inhibition of Plasmodium falciparum with IC(50)'s of 15 and 8.4 μM, respectively.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

M5571
Miltefosine, ≥98% (perchloric acid titration)
C21H46NO4P
P4405
Podophyllotoxin
C22H22O8