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Bioorganic & medicinal chemistry letters

Design driven HtL: The discovery and synthesis of new high efficacy β₂-agonists.


PMID 21652207

Abstract

The design and synthesis of a new series of high efficacy β(2)-agonists devoid of the key benzylic alcohol present in previously described highly efficacious β(2)-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β(2)-adrenoceptor crystal structure, other biophysical data and modeling studies.