EMAIL THIS PAGE TO A FRIEND

Biochimica et biophysica acta

Pyridoxal phosphate: biosynthesis and catabolism.


PMID 21767669

Abstract

Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a singlet oxygen scavenger and has protective effects against oxidative stress in fungi. Enzymes utilizing vitamin B(6) are important targets for therapeutic agents. This review provides a concise overview of the mechanistic enzymology of vitamin B(6) biosynthesis and catabolism. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

74006
Isopyridoxal hydrochloride, ≥98.5% (HPLC)
C8H9NO3· HCl