EMAIL THIS PAGE TO A FRIEND

Journal of natural products

Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark.


PMID 21985060

Abstract

From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (rutarin (3), seselin (4), suberosin (5), demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7α-obacunyl acetate (11). The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 μg/mL.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

T5509
Trigonelline hydrochloride, analytical standard
C7H7NO2 · HCl
91890
Trigonelline hydrochloride, ≥98.0% (AT)
C7H7NO2 · HCl