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Bioorganic & medicinal chemistry letters

Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents.


PMID 22225635

Abstract

We herein report the synthesis, biological activity and structure-activity relationship of derivatives of 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and benzo[d]imidazole. A lead compound 6o demonstrates potent anti-proliferative activity and the ability to induce cancer cell apoptosis.

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D147206
5,6-Dimethylbenzimidazole, ≥99%
C9H10N2