EMAIL THIS PAGE TO A FRIEND

Angewandte Chemie (International ed. in English)

Engineering cell surfaces for orthogonal selectability.


PMID 23239476

Abstract

Vectors have been constructed that express the chitin-binding domain (ChBD) on eukaryotic cell surfaces. The ChBD is linked to enhanced green fluorescent protein (EGFP) through a protein that spans the plasma membrane. This binding functionality does not have a counterpart in eukaryotes, thereby endowing the modified cell surface with a property that is orthogonal to animal cells.