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Pharmacological research

Blood kinetics of sulfamonomethoxine and oxytetracycline following intrauterine spray injection in dairy cows.


PMID 2330344

Abstract

Intrauterine administration was performed in six Friesan cows with a disposable spray preparation containing 3 g of sulfamonomethoxine and 3 g of oxytetracycline, in order to investigate their serum kinetics. Sulfamonomethoxine levels were determined by a reversed-phase HPLC method, whilst oxytetracycline quantities were detected by a microbiological method. The sulphonamide had a peak 1.17 h after the administration, the tetracycline reached its highest concentration after 8 h. The bioavailability of both drugs was low and detectable drug amounts were no longer recovered after 24 h.

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S0508
Sulfamonomethoxine
C11H12N4O3S