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Computer methods in biomechanics and biomedical engineering

Effects of amlodipine and adenosine on coronary haemodynamics: in vivo study and numerical simulation.


PMID 23405966

Abstract

Amlodipine (AMLO) is a calcium channel blocker with vasodilating properties, in which the specific effects on the coronary circulation are not fully known. Coronary flow velocity-pressure (F/P) curves were obtained at rest and during administration of AMLO (10xa0mg to 20xa0mg iv) or adenosine (ADO, 1xa0mg ic) in 10 normal subjects (six women, age 48xa0±xa014xa0years). F/P curves were reproduced in a numerical simulator of systemic and coronary circulations (CARDIOSIM(©)) by adjustment of coronary resistance ( >xa0orxa0100xa0μm vessels resistance from EPI to ENDO. ADO effects were mimicked by reducing resistance of both>100xa0μm andxa0andxa0