EMAIL THIS PAGE TO A FRIEND

Drug metabolism reviews

Synthesis of fatty acid ethyl esters in mammalian tissues after ethanol exposure: a systematic review of the literature.


PMID 23713893

Abstract

The ability to undergo non-oxidative metabolism from ethanol to fatty acid ethyl esters (FAEEs) varies greatly among tissues and organs. To gain a greater understanding of non-oxidative ethanol metabolism to FAEE, we aimed to collect all published data on FAEE synthesis in mammalian organs and tissues to identify all tissues, organs, and enzymes that are known to, or likely possess FAEE-synthetic activity. A systematic search for relevant papers was performed and two independent reviewers examined potentially relevant abstracts (articles on FAEEs that pertain to ethanol exposure) to determine whether they met the inclusion criteria. Information on FAEE synthesis was retrieved from papers meeting the inclusion/exclusion criteria and summarized by organ/tissue/matrix examined. The systematic search through four databases yielded 78 articles that investigated FAEE synthesis by tissues, tissue fractions and cell lines, and 29 articles that attempted to purify and/or characterize the enzymes involved in FAEE synthesis. Two enzyme activities have been studied: FAEE synthase (FAEES, which conjugates ethanol and free fatty acid) and acyl-CoA: ethanol O-acyltransferase (AEAT, which conjugates ethanol and fatty acyl-CoA). Both activities are expressed by a variety of different enzymes. FAEES activity is the most widely studied and has been purified from several tissues and shown to be associated with several well-known enzymes, while the identity of enzymes possessing AEAT activity remains unknown. The organs and tissues that have been shown to synthesize FAEEs are discussed, with special emphasis on the studies that attempted to elucidate the enzymology of FAEE synthesis in those tissues.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

24102
Ethanol, absolute, ≥99.8% (GC)
C2H6O
24105
Ethanol, puriss., meets analytical specification of Ph. Eur., BP, 96.0-97.2%
C2H6O
24194
Ethanol, absolute, denaturated with 0.5-1.5 Vol.% 2-butanone and approx. 0.001% Bitrex (GC), ≥98% (GC)
C2H6O
E-034
Ethanol Calibration Kit, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-040
Ethanol-10, 10 mg/dL in H2O, pack of 10 × 1.2 mL ampules, certified reference material
C2H6O
E-031
Ethanol-100 (10 ampules/kit), 100 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-038
Ethanol-100 (5 ampules/kit), 100 mg/dL in H2O, ampule of 5 × 5 mL, certified reference material
C2H6O
E-041
Ethanol-150, 150 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-056
Ethanol-20 (10 ampules/kit), 20 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-043
Ethanol-20 (5 ampules/kit), 20 mg/dL in H2O, ampule of 5 × 5 mL, certified reference material
C2H6O
E-032
Ethanol-200 (10 ampules/kit), 200 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-039
Ethanol-200 (5 ampules/kit), 200 mg/dL in H2O, ampule of 5 × 5 mL, certified reference material
C2H6O
E-035
Ethanol-25, 25 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-033
Ethanol-300, 300 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-045
Ethanol-40, 40 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-036
Ethanol-400 (10 ampules/kit), 400 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-044
Ethanol-400 (5 ampules/kit), 400 mg/dL in H2O, ampule of 5 × 5 mL, certified reference material
C2H6O
E-029
Ethanol-50, 50 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-053
Ethanol-500, 500 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-030
Ethanol-80, 80 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material
C2H6O
E-037
Ethanol-80, 80 mg/dL in H2O, ampule of 5 × 5 mL, certified reference material
C2H6O
187380 Ethyl alcohol, denatured, reagent grade
459844
Ethyl alcohol, Pure, 200 proof, ACS reagent, ≥99.5%
C2H6O
E7023
Ethyl alcohol, Pure, 200 proof, for molecular biology
C2H6O
493546
Ethyl alcohol, Pure, 200 proof, meets USP testing specifications
C2H6O
459828
Ethyl alcohol, Pure, 200 proof, HPLC/spectrophotometric grade
C2H6O
E7148
Ethyl alcohol, Pure, 190 proof, for molecular biology
C2H6O
270741
Reagent Alcohol, for HPLC
245119
Reagent Alcohol, spectrophotometric grade
277649
Reagent Alcohol, anhydrous, ≤0.003% water