EMAIL THIS PAGE TO A FRIEND

Oncogene

The male-specific factor Sry harbors an oncogenic function.


PMID 23893245

Abstract

Sgf29, a component of the SPT-ADA-GCN5 acetyltransferase (SAGA) complex, binds H3K4me2/3 marks and leads to histone H3 acetylation. Previously, we found that downregulation of Sgf29 suppresses c-Myc-mediated malignant transformation. Nonetheless, the upstream regulator of the Sgf29 gene is not yet known. Here, we report that Sry (sex-determining region Y), an HMG (high-mobility group) domain containing transcription factor, directly upregulates Sgf29 gene expression. Sry expression was deregulated in two out of the four tested male rodent hepatocellular carcinoma (rHCC) cell lines. Luciferase reporter and chromatin immunoprecipitation assays indicated that Sry could bind HMG-boxes in the proximal promoter region of the Sgf29 gene. Knockdown of Sry robustly lowered anchorage-independent growth, invasiveness and tumorigenicity of rHCC cells, whereas ectopic expression of Sry conferred more malignant properties. Thus, these data show that Sry is involved in male-specific malignant conversion of rHCCs via Sgf29 upregulation.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB1100050
Anti-LDHA (216-228) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
SAB1406077
Anti-LDHA antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
AV54777
Anti-LDHA antibody produced in rabbit, affinity isolated antibody
AV37737
Anti-MTA1 (AB1) antibody produced in rabbit, IgG fraction of antiserum
AV37738
Anti-MTA1 (AB2) antibody produced in rabbit, IgG fraction of antiserum
SAB2500651
Anti-MTA1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
M7693
Anti-MTA1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
HPA005544
Anti-MTA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB4503553
Anti-MTA1 antibody produced in rabbit, affinity isolated antibody
SAB1410855
Anti-ODC1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
HPA000662
Anti-SLC25A21 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2102186
Anti-SLC25A21 antibody produced in rabbit, affinity isolated antibody
SAB2105556
Anti-SLC25A21 antibody produced in rabbit, affinity isolated antibody
SAB4503521
Anti-SLC25A21 antibody produced in rabbit, affinity isolated antibody
SAB1406478
Anti-SRY antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB2102304
Anti-SRY antibody produced in rabbit, affinity isolated antibody, lyophilized powder
SAB4500015
Anti-SRY antibody produced in rabbit, affinity isolated antibody
SAB4100133
Monoclonal Anti-LDHA antibody produced in mouse, clone LDHA-C47, culture supernatant
WH0009112M2
Monoclonal Anti-MTA1 antibody produced in mouse, clone 4D11, purified immunoglobulin, buffered aqueous solution
SAB1404673
Monoclonal Anti-MTA1 antibody produced in mouse, clone 4D5, purified immunoglobulin, buffered aqueous solution
WH0004953M1
Monoclonal Anti-ODC1 antibody produced in mouse, clone 2G5, purified immunoglobulin, buffered aqueous solution
SAB1403412
Monoclonal Anti-SLC25A21 antibody produced in mouse, clone 2C9, purified immunoglobulin, buffered aqueous solution