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Angewandte Chemie (International ed. in English)

Arylation of diazoesters by a transient N-H insertion organocascade.


PMID 24038873

Abstract

It takes two: A unique organocatalyzed cascade for the unsymmetric double arylation of α-nitrodiazoesters is described. This organocascade features the strategic use of carbene-activating anilines in conjunction with a urea catalyst, thus allowing for the synthesis of pharmaceutically attractive α-diarylesters through a transient NH insertion process.

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