EMAIL THIS PAGE TO A FRIEND

The American journal of physiology

Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP.


PMID 2421587

Abstract

From structure-activity relationship studies of rat growth hormone-releasing factor (rGFR) on the vasoactive intestinal peptide (VIP) receptor in an in vitro preparation of exocrine pancreas, we predicted that [4Cl-D-Phe6, Leu17]VIP would be a competitive antagonist for the action of VIP. Micromolar concentrations of synthetic [4Cl-D-Phe6, Leu17]VIP competitively antagonized VIP-stimulated amylase release in the pancreatic preparation and VIP-stimulated short-circuit current changes in a colonic tumor cell line. In addition, [4Cl-D-Phe6, Leu17]VIP inhibited amylase release stimulated by rGRF, high concentrations of secretin (agents that act through the VIP receptor), and peptide contaminants in a preparation of natural glucagon. Finally, [4Cl-D-Phe6, Leu17]VIP did not inhibit the action of agonists for the secretin, GRF, or glucagon receptors.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

V4380
[D-p-Cl-Phe6, Leu17]-Vasoactive Intestinal Peptide human, porcine, rat, ≥97% (HPLC)
C148H239ClN44O42