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Molecular carcinogenesis

Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder.


PMID 24293253

Abstract

Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.

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EHU025841 MISSION® esiRNA, esiRNA human HDAC1 (esiRNA1)