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Andrologia

Relevance of seminal plasma nitric oxide levels and the efficacy of SSRI treatment on lifelong premature ejaculation.


PMID 24354496

Abstract

The aim of this study was to determine the relevance of seminal plasma nitric oxide (NO) levels and the efficacy of selective serotonin reuptake inhibitor (SSRI) treatment on premature ejaculation. A total of 16 men (aged 32.18xa0±xa03.32) with lifelong premature ejaculation [intravaginal ejaculation latency time (IELT) <1xa0min] and 11 healthy men (control group) were included in this study. The healthy men formed Group 1, and the patients were randomly categorised into two groups. Group 2 patients received 20xa0mgxa0day(-1) of paroxetine, and Group 3 patients received 50xa0mgxa0day(-1) of sertraline for 4xa0weeks. Baseline and post-treatment findings were compared among the three groups. Mean baseline seminal NO levels in men with premature ejaculation were significantly higher than in the healthy control group (32.24xa0±xa05.61xa0μmxa0l(-1) versus 19.71xa0±xa03.50xa0μmxa0l(-1) , respectively) (Pxa0